Transcribing and translating products from the genome is regulated across time and space, at multiple levels, to ensure the correct development of an organism and its response to diverse environmental cues. The genome of the marine chordate Oikopleura dioica has a highly compacted and deeply modified architecture compared to other animal genomes. I study different aspects of its regulation, including:
- spliced-leader led RNA trans-splicing
- nutrient-dependent translational control
- dynamics of promoter usage
- sex-specific epigenetic modifications
- recovery from growth arrest
- the developmental transcriptome
My research combines bioinformatics methods with experimental approaches and makes extensive use of next generation sequencing technologies.